Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
Answer:
Heredity is a term that refers to something we have gained from our parents, they can be some physical traits like appearance or behavioral traits like generosity, ethics etc.
When we talk about development of an individual, science has proved that both heredity and environment play a crucial role. There is no doubt that certain things are predetermined in our genetic make up like our height, weight and complexion etc but there are several ways in which environment influences and modifies those traits.
Let's take some examples:
- A kid is born in Africa whose parents inherited just appropriate and ideal height and intelligence to him, But he was surrounded by the conditions where he could not get sufficient food , minerals and nutrients that hindered not only his physical growth and development but his intelligence level did not reach that potential too that was predetermined in his genes. So, we can say that environment influenced the kid and modified the traits he inherited from parents.
- Similarly, there are many boys that inherit fair complexions from their parents but they have a lot of sun exposure due to out door sports and activities. So, parents observe that after teens their complexion is getting towards darker tone although in preadolescence they were just as fair as other siblings. This is proven by studies that sun exposure turns the skin tan and darker than original tone.
Therefore, we can say that both Heredity and environment play an important role in determining human development and behavior.
Hope it help!
Hey There! The "SI" unit is 0.001 grams! Hope this helps!
Cohesion. Cohesion is the property of water that attracts other water molecules so they can stick together. Water is sticky because it has positive and negative charge in the oxygen and hydrogen ends that attracts one water molecule to another. Adhesion is also a property of water that attracts it from other substances, making it easy for water to travel upwards through transpiration.
Answer:
- Bird wings and dragonfly wings are both used for flight: Analogous structure
- Clams and snails both have similar muscle structure even though the muscles do different jobs: Homologous structure
- Human and giraffe necks both have 7 vertebrae because we are related: Homologous structure
- The flaps of a Venus flytrap have a similar makeup to oak leaves: Homologous structure
Explanation:
Analogous structures are similar structures that have the same or similar functions in unrelated organisms. Analogous structures aren't the result of evolutionary relationships among organisms (i.e., they were not inherited from a common ancestor). On the other hand, homologous structures are structures inherited from a common ancestor. Homologous structures may or may not have an identical function, but they are the result of evolutionary relationships among organisms and, therefore, they are genetically related.
