The largest is the Biosphere
When cells in a body are not working properly and normally, they cause disruption in the body homeostasis.
Homeostatis is characterized as balance in the body but when there is any disturbance in the body, it breaks down the balance and cause imbalance. For example in the case of diabetes in which body fails to maintain the good amount of glucose in blood which results in imbalance the body which is why diabetic patients are asked to maintain and monitor their body sugar level to maintain homeostatis.
How many trees were cut down during the year?
How many new factories opened last year?
How many factories in the community use fossil fuels?
hope this helps you