Aneuploidy can result in the final daughter cell if the spindle fibers fail to pull a chromosome toward the pole as in case of non-disjunction.
Explanation:
Aneuploidy is a condition which arises when one or more chromosome is missing in the final daughter cells.
Non-disjunction refers to the failure of chromosomal or chromatid segregation or separation during cell division. This results in erroneous meiosis or mitosis leading to the formation of final daughter cells or gametes with an extra or missing chromosome. This condition is aneuploidy.
Failure of separation or segregation of:
- Homologous chromosomes occur in Anaphase I, affects four daughter cells.
- Sister chromatids during Anaphase II, affects two daughter cells
This failure of separation leads to aneuploidy chromosomal abnormalities like monosomy, trisomy, etc which can cause diseases like Down’s syndrome, Turner’s syndrome etc.
Cells divide for many reasons. For example, when you skin your knee, cells divide to replace old, dead, or damaged cells. Cells also divide so living things can grow. When organisms grow, it isn't because cells are getting larger.
Phylum, it is the second largest group.
Answer:
Delta binds to the Notch receptor and this binding produces the cleavage of its intracellular domain, which subsequently enters into the cell nucleus to bind with a repressor in order to activate the transcription
Explanation:
The Notch signaling pathway is initiated when Notch receptors on the cell surface bind to the Delta ligand, which activates Notch signaling in cells next to it. In the receiving cell, Delta–Notch binding triggers the cleavage of the Notch intracellular domain called Nic (intracellular Notch). Subsequently, Nic enters into the cell nucleus where it releases repression on Suppressor of Hairless (Su(H)) class transcription factors, thereby activating the transcription of target genes.
