<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
</span>
Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
Answer:
Your bloodstream.
Explanation:
The cells in your pancreas produce insulin which needs to be sent to the rest of your body to tell your cells to take in glucose (sugar) for energy. In order to get sent out of the pancreas' cells, the insulin needs to go through your bloodstream.
<u>Answer:</u>
Recent evidence suggest that feathers evolved from scales and suggest that 'feathers and pycnofibers' could be homologous.
<u>Explanation:</u>
- One of the major difficult issue related to bird evolution is the evolution of feathers.
- Feathers are considered as the most 'complex integumentary structures' which are found in vertebrates.
- Evolutionary developmental biology suggests that the 'planar scale structure' is been modified for developing into feathers by 'splitting' to form web like structures.
- Scales and Feathers consist of 'two distinct form of keratin' so it was thought that 'each type was exclusive skin structure' but recent study suggests that they are developmental expressions of same skin structures.
By takeing a big nice juscy buns and banging it sooo hard
