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Ulleksa [173]
2 years ago
8

You are investigating the cell division of a newly identified pathogen that has a rod shape. The organism's genome has been sequ

enced and thre follwing genes were determined to be associated with establishing the bacterial infection;
1. fla - gene responsible of expressing flagellin protein
2. cap - gene responsible of capsule formation
3. tox - unidetified virulence factor
Use the " Molecular Koch's Postulates" to identify the "tox" gene and if it is associated with the virulence of rod shape bacterial infection.
Be concise yet thorough in your answer indicating your hypothesis and how will you design your experiment to excute each step of the molecular Koch's postulates. Please use the information below and on the link to understand the molecular Koch's postulates.
The postulates as originally described by Falkow are as follows:
"The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species." Additionally, the gene in question should be found in all pathogenic strains of the genus or species but be absent from nonpathogenic strains[citation needed].
"Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or virulence." Virulence of the microorganism with the inactivated gene must be less than that of the unaltered microorganism in an appropriate animal model.
"Reversion or allelic replacement of the mutated gene should lead to restoration of pathogenicity." In other words, reintroduction of the gene into the microbe should restore virulence in the animal model.
Biology
1 answer:
ch4aika [34]2 years ago
7 0

Answer:

Explanation:

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what's the difference between these- single or multiple genes, and dominant, recessive or sex-linked genes
Veseljchak [2.6K]
A single gene disorder is one that's known to be caused by a single gene. Multiple gene disorders, however, can be caused by multiple gene combinations and other factors. Dominant genes are always expressed in the offspring, while recessive genes are only expressed if the offspring recieves the recessive gene from both parents. Sex-linked genetic disorders occur most often in men, and are caused by a single-gene disorder gene being on the X chromosome but not the Y, so that the offspring needs only one recessive gene to have the trait/disorder.

Does this help? Any more questions?
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3 years ago
a specfic mutation in a certain animal leads to abnormal development of the heart and kidney, resulting in miscarriage. Why did
Otrada [13]

Answer:

These kinds of mutations are referred to as Lethal mutations

Explanation:

This type of mutation deleteriously affects the vital genes that are responsible for the core functions of the body. The heart supplies blood to the body organs for nutrients and oxygen while kidneys filter out toxins and end products of metabolism. Mutations in genes for development of these organs will be deadly.

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8 0
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Vadim26 [7]

Answer;

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