Answer:
They can be harmful.
Explanation:
Prokaryotes are the organism that do not have nucleus and lacks the membrane bound organelle. Eukaryotes have well defined nucleus and contains the membrane bound organelle.
Th prokaryotes includes the small bacteria and other small organism. The bacteria can cause harmful disease in humans. They can cause cancer or can mutate the genetic constitution of the organisms. The prokaryotes can destroy the products that are harmful and their consumption can destroy the human health.
Thus, the correct answer is option (3).
So one the left is substrate and active site
Probably the intertidal zone, as I reason the tides would affect life dramatically. High and low tide would affect land and ocean creatures in this zone too often where as the coastal and open oceans have constant properties.