Oncogenes are most like the gas pedal on a car, while tumor suppressor genes are most like the brakes on a car. Oncogenes and tumor suppressor genes are mutated in cancer cells.
Oncogenes are genes overexpressed in cells in which they should not be expressed, thereby leading to cancer.
Some examples of oncogenes are growth factors such as, for example, the Platelet-derived growth factor (PDGF) or Epidermal growth factor (EGF).
Conversely, tumor suppressor genes are genes that act to regulate cell division and replication, thereby their inactivation also leads to cancer.
A well-known example of a tumor suppressor gene is the p53 gene that acts to control cell division and apoptosis (programmed cell death).
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<em>For example,</em>
<em> consider a mountain whose summit is 5,000 feet (1,500 m) in elevation, but somewhere on the way up, the trail goes back down 250 feet (76 m). ... </em>
<em>If one hikes over five hills of 100 vertical feet each, the cumulative elevation gain is 5 × (100 feet (30 m)) = 500 feet (150 m).</em>
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Aids/ HIV
Cancer
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Which signal are you talking about?
