A nucleus present in the pons of brainstem responsible or involved in physiological responses to panic and stress is known as locus ceruleus.
Basically, locus ceruleus is responsible for the primary production of norepinephrine in the brain. The nucleus transfers the norepinephrine to whole cerebral cortex along with various other structures like amygdala, cerebellum, hippocampus, and spinal cord.
So, when there is a panic disorder due to norepinephrine dysregulation at the brainstem area which will be definitely locus ceruleus.
