Answer and Explanation:
1. Amino-acid sequence is the primary structure of a protein
2. Alpha helices, beta sheets and coiled coils refers to the protein folding and they represent the secondary structure of a protein
3. Protein ensemble formed by alpha helices, beta sheets and coiled coils represent the tertiary structure of a protein
4. Macromolecules with multiple polypeptides form globular or fibrous protein structures (quaternary structure)
<span> because if the shape of the enzyme changes it may not function or it may function differently.
hope this helps</span>
Answer:
A mutation in Ras protein which will cause hyperactivity will eventually lead to cancer.
Explanation:
Ras protein was first discovered in Rous sarcoma virus (RSV) and it is a proto-oncogene product. In normal conditions, it plays an important role in cellular signalling but in case of gain of function/hyperactivity it gets converted into cellular oncogene. In several types of cancers a point mutation has been reported in Ras protein.
Just like G protein, it is also a GTPase switch protein but unlike G protein which is trimeric, it is monomeric. In the plasma membrane, it is attached with the help of lipids like prenyl or palmitoyl groups. During signal transduction pathway when it gets activated, it downstream activates MAPK pathway and causes gene expression but when it gets hyperactivated it causes over expression of genes leading to cancer.
