<span>epidermolysis bullosais caused by the 12th chromosome
</span>
Fusion and gravity
Fusion and gravity keep the sun from blowing itself up. A large amount of energy is released by the
sun. Protons are fused together to form helium atoms due to the high heat and
pressure at the center of the sun. The Sun does not blow itself up from the
outer pressure of nuclear fusion in as much as the inner force of gravity
balances it.
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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(D)an atom can join with other kinds of atoms.
Basically he explained what a molecule is.
<span>The sequence of alternation of generation is; gametes->zygote->sporophyte->spores->gametophyte->gametes.
The attached diagram shows clearly this looped cycle. Alternation of generation
occurs in a more advanced land plant that
has distinct
haploid and diploid phases in their life
cycle. The diploid phase usually involves
the sporophyte while the haploid phase involves the gametophyte</span>
