Answer:
D. The frequency of the Ellis-van Creveld allele is 0.0447 in the isolated population and 0.0026 in the general population, which suggests that genetic drift has occurred in the isolated population.
Explanation:
If we assume that one gene is involved in Ellis-van Creveld syndrome and we name that gene with A, then the genotype of the syndrome would be aa.
In population 1, the frequency of the syndrome is 1/150000=0.0000066(it is the frequency of the aa gentotype)
In population 2, the frequency of the syndrome is 1/500=0.002
According to Hardy-Weinberg equilibrium
p2+2pq+q2=1 (p2 is the frequency of the dominant homozygous, 2pq is the frequency of heterozygous and q2 is the frequency of the recessive homozygous).
q or the frequency of the Ellis-van Creveld allele in Population 1 is =0.0026
q or the frequency of the Ellis-van Creveld allele in Population 2 is = 0.0447