The doctor will check for the level of activity of TPMT and then adjust her medications according to that.
What is TPMT?
Thiopurine methyltransferase (TPMT) is indeed an enzyme that disintegrates (metabolises) the thiopurine class of medications. These medications are approved to treat various immune-related conditions as well as blood disorders because they suppress the immune system (e.g., leukemia). To ensure that people receiving thiopurine drug therapy can metabolise the drugs, the level of TPMT enzyme activity or the genetics underlying the enzyme's activity are assessed prior to the start of the therapy.
Azathioprine, mercaptopurine, as well as thioguanine are a few thiopurine examples. These drugs are used to treat conditions like autoimmune disorders, inflammatory bowel disease, as well as acute lymphoblastic leukaemia. In order to delay as well as prevent organ rejection, they may also be prescribed to people who have received organ transplants.
Hence the answer is, based on the level of TPMT, the medications will be provided.
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If the bicuspid valve does not close completely, blood can flow backwards into the heart. This is regurgitation, also called aortic valve insufficiency. The heart then must pump that same blood out again, causing strain on the heart's lower left chamber, the left ventricle.
