Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
A. Estazolam
Explanation:
Estazolam help people fall asleep but can cause paranoid or suicidal ideation and impair memory, judgment, and coordination
Answer: Venous bleeding
Explanation:
The external bleeding can be define as the bleeding in which the blood leaves the body due to external injury. The internal bleeding is the bleeding which occurs inside the body that may occur due to internal injury. There are about three types of external bleeding named as capillary, venous and arterial.
Capillary bleeding is most common and results from damage of tiny capillaries. Arterial bleeding is one of the serious type. The blood will spurt out from damage artery. It involves large amount of blood loss.
Venous bleeding occurs when a vein is subjected to cut, blood will steadily flow. If a deep vein is cut then the bleeding cannot be controlled and it can be fatal.
Answer:
only qualified persons are licensed to provide dental care and violators of laws and rules regulating the practice of dentistry are sanctioned as appropriate.
Explanation:
Source: TSBDE.
I'm also Texan and have the Brainly Medical Guru badge.
Answer:
A. headache
Explanation:
Nitroglycerin side effect is headache.
