Answer:the 1st one is 2 1/2 ml the 2nd is um 1ml the 3rd is 4 1/4ml and the 5th is
23ml
Explanation:
Answer:
The statement is true.
Explanation:
The results of the investigations carried out in relation to the link between cortisol secretion and personality reveal differences in the reported evidence. Some of this research indicates that personality traits or disorders play a relevant role in individual differences in the endocrine response to cortisol, both in its basal levels and in the face of stressful stimuli.The relationship between antisocial personality and cortisol levels has been described in several investigations. Among the most reported neuroendocrinological abnormalities in antisocial men is a decrease in cortisol secretion levels. In this regard, Moss, Vanyukov and Martin conducted a case control study comparing cortisol secretion in stressful situations in children between 10 and 12 years of age at risk of presenting aggressive and abusive behavior in adolescence based on their family history. The groups were formed in relation to the presence or absence of a family history of aggression and substance abuse, specifically in the parents. The results found showed that children had a higher risk of antisocial behavior, if their parents had a history of substance abuse and violent behavior, they had lower levels of cortisol secretion in stressful situations than children in the control group whose parents did not present these behaviors negative. The researchers argue that these results could be indicating that a lower increase in cortisol levels in the face of stressful situations could be a biological marker of future antisocial adolescents. Likewise, a longitudinal study with 38 school-age children who had symptoms of aggressive behavior (clinically reported), who were assessed for the circadian rhythm of cortisol in saliva during the second and fourth years of schooling; reported the relationship between the decrease in HPA axis activity and the presence of severe and persistent aggressive behaviors.
Answer:
The answer is B, C, E
Explanation:
Older patients tend to be people with multiple pathologies, which forces them to be taking different medications for each of them, this polypharmacy can lead to an adverse alteration in the senile patient. knowing that they are older adults they will have a certain degree of renal dysfunction which will not allow the elimination of the metabolites of these medications.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
