Answer:
Responsibilities that counselors are charged with to assure the protection of clients rights and the promotion of client welfare: 1. Identify the clinical issue 2. Identifying the system issue 3.
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Answer:
Moderna's COV-19 vaccine is 100% effective in children ages 12 to under 18, the company said last month
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Answer:
Intrusion on movement
Explanation:
When the external fetal monitor is applied to the abdomen of a pregnant lady, movement is discouraged. Because, movement may alter the tracing of fetus and the nurse may not exactly know the heart rate, Respiration rate and movement of fetus. Hence, the mother should remain static so that the true movement and breathing of fetus can be matched with the monitor reading accurately.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
