How does the cell regulate the substrate specificity of ribonucleotide reductase to maintain equal amounts of all four deoxynucl
eoside triphosphates (dNTPs)? Choose one or more: A. When dTTP is bound to the specificity site, more dCDP is produced. B. When dGTP is bound to the specificity site, more dUDP is produced. C. When dTTP is bound to the specificity site, more dGDP is produced. D. When dGTP is bound to the specificity site, more dADP is produced.
The correct answer is A When dTTP is bound to the specificity site, more dCDP is produced
Explanation:
Ribonucleotide reductase catalyzes the conversion of ribonucleotide to deoxyribonucleotide.
When dTTP is bound to the specificity site at that time dCDP is produced.The So formed dCDP is converted to dUDP by the help of dCDP deaminase.The dUDP is then converted to dUTP by phosphorylation.
Finally the dUTP is converted to dTTP by the catalytic activity of thymidylate synthase with the presence of N5 N10 methylene tetrahydrofolate.
Thus equal amount of deoxyribonucleoside triphosphates are maitained by the cell.
