Question

What are some drawbacks to using mice in genetic studies?

Answer 1

Explanation:

Genetically altered mice have served to recapitulate human diseases, including cancer, glaucoma, heart disease, and diabetes. However, despite their genetic similarity to humans, mouse models are criticized for their failure to accurately mimic human disease phenotypes.

Why it's bad to use mice as an experiment:

The use of mice as model organisms to study human biology is predicated on the genetic and physiological similarities between the species. Mice are less reliable as models of human disease, however, because the networks linking genes to disease are likely to differ between the two species.

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Answer 2

Answer:

One drawback to using transgenic, knock-in, and knock-out mice to study human diseases is that many disorders occur late in life, and when genes are altered to model such diseases, the mutations can profoundly affect development and cause early death.

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