Question

Q6.7. If a person is heterozygous for the triangle32 allele of the CCR5 gene, how many of the four daughter cells produced by have the3

Answer 1

Given the characteristics of hereditary genetics, if a person is heterozygous for a given allele, of the four daughter cells produced, the amount that would have the gene is dependent on the spouse's genetic makeup but ranges from 50-100%.

When we say that an individual is heterozygous for a given trait, we mean that of the two alleles that this individual possesses for the given trait, one is of the desired type and one is not. Whereas an individual who is hom-ozygous for a given trait will have both alleles of the same kind.  

For example, if we were to look at the allele for blue-colored eyes, a heterozygous individual will have one allele which corresponds to blue coloration, and one allele that corresponds to another color, and a hom-ozoygous will have both alleles for blue eyes. In order to accurately predict the expression of the gene in the offspring of an individual, we use a punnet square (see attached image).

Assuming that the allele in question is dominant in nature, this allows us to see that of the four daughter cells of an individual that is heterozygous for the given allele, the number that will have the triangle32 allele are:

• 50% (2) if crossed with a spouse who does not have the allele
• 75% (3) if crossed with a spouse who is also heterozygous for the allele
• 100% (4) if crossed with a spouse who is hom-ozygous for the allele

In conclusion, we can say that the outcome of the cross is entirely dependent on the genetic makeup of the spouse, as well as the dominant or recessive nature of the allele in question, but can accurately predict an outcome in the range of 50-100%.

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