Agonists activate the receptor thereby <u>increasing</u> activity at the synapse while antagonists generally prevent agonists from activating the receptors thereby <u>decreasing</u> activity at the synapse.
An agonist is the component that has the ability to increase the activity carried out by another substance.
The agonists work from their faculty of coupling to a cell-type receptor, in this way, they manage to generate a certain action in the cell.
The antagonists are the compounds that cause the opposite when they bind to the receptor, they cause a blockade by decreasing the activation of a synaptic receptor.
Therefore, we can conclude that agonists are compounds capable of increasing the action of synapse and blockers (antagonists) decrease activity at the synapse.
