Hi the rectal route is preferred over the oral route because- rectal medications are usually not subject to first pass metabolism.
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If an A (Adenine) were swapped for a T (Thymine) it will lead to A TRANSVERSION TYPE OF POINT MUTATION.
Replacement of an A with a T is a transversion type of point mutation because in transversion the purine is replaced with a pyrimidine. Since in this case only one nucleotide is replaced, it is a point mutation.
