Using permutations, it is found that there are 12 ways to pick a sequence of two different letters of the alphabet that appear in the word Crab
.
The order in which the letters appears is important, as for example, ab is a difference sequence than ba, hence the <em>permutation formula</em> is used.
Permutation formula:
The number of possible permutations of x elements from a set of n elements is given by:
In this problem, 2 letters are picked from a set of 4, hence:

There are 12 ways to pick a sequence of two different letters of the alphabet that appear in the word Crab
.
For more on permutations, you can check brainly.com/question/24905801