Question

When Ashleigh inquired about her family's medical history, she found out that Uncle Albert's mother (Ashleigh's grandmother) also had sickle cell disease, but Uncle Allbert's father did not. One of her uncle's six children also had the disease. However, Ashleigh's father, who is Albert's only sibling, did not have sickle cell disease, nor did Ashleigh's mother. Ashleigh's two siblings showed no signs of the disease either. What pattern of heredity does the sickle cell trait follow? Cite evidence from your textbook and its clues to support your conclusion. Based on your answer to this question, what can you conclude about the inheritance of sickle cell disease in Ashleigh's family? What might be Ashleigh's chances of being a carrier of the sickle cell trait?

Answer 1

The sickle cell pattern based on the family history of Ashleigh isan:

• Autosomal recessive pattern

Based on the given question, we cam see that in the medical history of Ashleigh's family, most of them have had the sickle cell disease which includes her grandmother, one of her uncle's six children has it too, but her father and grandfather did not have the disease.

With this in mind, the inheritance of the sickle cell disease in the family of Ashleigh is one which is autosomal recessive as it affects some people and doesn't affect others because of the pairing of the chromosome which contains the sickle cell trait.

Read more about sickle cell here:

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