Cyclic nucleotides cAMP and cGMP are part of almost all major cellular signaling pathways. Phosphodiesterases (PDEs) are enzymes that regulate the intracellular levels of cAMP and cGMP. Protein kinase A or cAMP-dependent protein kinase mediates most cAMP effects in the cell. Over the last 25 years, various components of this group of molecules have been involved in human diseases, both genetic and acquired. Lately, the PDEs attract more attention. The pharmacological exploitation of the PDE’s ability to regulate cGMP and cAMP, and through them, a variety of signaling pathways, has led to a number of new drugs for diverse applications from the treatment of erectile dysfunction to heart failure, asthma, and chronic obstructive pulmonary disease. We present the abstracts (available online) and selected articles from the proceedings of a meeting that took place at the National Institutes of Health (NIH), Bethesda, MD, June 8–10, 2011.
Answer:
the answer is the first one (a)
The oxygen family, also called the chalcogens, consists of the elements found in Group 16 of the periodic table and is considered among the main group elements. It consists of the elements oxygen, sulfur, selenium, tellurium and polonium.
Scientists use carbon-14 to date ancient fossils.
Plants and animals absorb carbon-14 produced by cosmic rays. The ratio of C-14 to C-12 is constant when they are alive.
When they die, the C-14 decays to C-12, and the ratio changes.
Carbon-14 has a half-life of 5730 years. Thus, the object loses half its C-14 every 5730 years.
Scientists can use the C-14 to C-12 ratio to date fossils up to 70 000 years old.
