Answer:
Potential targets:
1- DNA methyltransferases
2- Chromatin modifiers such as histone acetyltransferases, histone deacetylases, histone methyltransferases, etc.
3- Components of the RNA interference (RNAi) machinery such as Dicer, Argonaute, etc.
Explanation:
Epigenetics can be defined as the study of any heritable change in the phenotype that does not involve modifications in the DNA sequence. Epigenetic mechanisms can be classified into three major types: 1-DNA methylation, 2-histone modifications (e.g., acetylation, methylation, phosphorylation, etc), and 3-regulatory non-coding RNAs (e.g., miRNAs, lncRNAs, siRNAs, etc) that modulate target gene expression via the RNA interference pathway. There are different types of proteins that are involved in these complex epigenetic mechanisms, and those cited above represent only some examples that can be used as therapeutic targets.
As we can see in the pedigree, both of the parents do not possess the trait, but one of the four offspring (marked with red) is expressing the trait.
Since the trait is recessive, the only way that is possible that the parents who do not possess the trait to have the offspring with the trait is that the parents are heterozygous for the trait. Meaning that both of the parents have one dominant allele and one recessive allele.
Answer:
Nutrient-rich blood flows into the liver from the intestines through the hepatic portal vein.