Answer and Explanation:
The mechanism of action of statins begins with the inhibition of a protein called HMG-CoA reductase, allowing its substrate to accumulate in the body and promote cholesterol reduction. At that moment, a transporter called OATP (Organic Anion Transporting Polypeptides) takes statins to the epatic tissue where they will be transformed and metabolized until they are eliminated through bile. This elimination is influenced by the P-glycoprotein, which is the main cause of the efflix presented by the bili. This process can get help from other molecules like some protease inhibitors, digoxin and cyclosporine.
The answer for this question would be Integument, digestive, respiratory and urogenital.
The largest system that contact with the external environment would be integument and digestive. That makes two system has normal flora of microbes and not sterile like the other systems. Normal flora of microbes will prevent the pathogen microbe grows so it gives some benefit.
Charlidamelio is overrated
