The Story of an Hour Theme of Freedom and Confinement. At first, freedom seems like a terrible thing to Mrs. Mallard, who's restricted in lots of ways: through her marriage, by her bad heart, and even inside her home, which she doesn't leave during "The Story of an Hour."
It is unsafe because it could give the baby defects.
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Gradual changes in the frequency of diseases over long periods are known as SECULAR TIME TRENDS. For example, the rate of mortality in USA due to coronary heart diseases over a period of time. Onset of puberty in girls is also a secular time trend.
Secular time trend is also referred as Secular Variation and Secular Drift.
Energy. A solute can only move against concentration gradients using active transport which requires energy