<em>Here's something I pulled together.</em>
Explanation:
The regeneration of nerves throughout the human body has been a subject of much interest in biology recently. The unique characteristics of both the central nervous system and the peripheral nervous system provide insights into the mechanisms occurring after once damage occurs. A good understanding of the differences between these mechanisms also may lead to new therapies for nerve-damaged patients, including stroke patients. Following injury, the nerves in the central nervous system of an adult mammal will not regenerate, while the peripheral nervous system will. These differences appear in every stage of axon regeneration.
Within hours of axotomy, the peripheral nervous system begins regeneration, ultimately growing neurons towards their targets. After a crushing injury to a peripheral nerve, axons successfully form new growth cones and begin directed regrowth. However, the opposite can be said for central nervous system axons. Instead, After the injury, the central nervous system axons retract. They also develop swollen endings that are called retraction cones, or “frustrated growth cones,”, due to their inability to form proper growth cones and continue with regeneration. The differences in the responses between the central nervous system and peripheral nervous system nerves are due to many factors. The intrinsic properties of the central nervous system axons, a growth inhibitory environment, and a lack of neurotrophic factors all play a role in inhibiting the growth of the axon.
Within Research advances in recent experiments, years focused, three areas have worked to further the field of axon regeneration. Studying the effects of the environment on the growth cone, axon growth, and the small GTPases involved in inhibiting regrowth have significantly affected the knowledge of axon regeneration.
<u>Hope this helps!</u>
