Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
<u>It takes two copies of the mutant gene.</u>
Explanation:
<em>One from each parent, to give somebody the all-out sickness. Numerous individuals have only one duplicate, the other being typical.</em>
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Hope this helped and have a great afternoon!
<em>~ChokieWokie~</em>
Answer:
The diagram is attached below.
Explanation:
when sodium and chlorine comes close together they form anion and cation. The compound formed is called sodium chloride.
Both atoms bonded together through ionic bond.
Ionic bond:
It is the bond which is formed by the transfer of electron from one atom to the atom of another element.
Both bonded atoms have very large electronegativity difference. The atom with large electronegativity value accept the electron from other with smaller value of electronegativity.
For example:
Sodium chloride is ionic compound. The electronegativity of chlorine is 3.16 and for sodium is 0.93. There is large difference is present. That's why electron from sodium is transfer to the chlorine. Sodium becomes positive and chlorine becomes negative ion.
Answer:
It depletes resources until there are no longer enough to sustain the population
Explanation:
