Answer:
Essentially there is not an answer. There are two different definitions.
A holoenzyme is an enzyme that needs to be together with a cofactor(s), required for activity.
In some cases, enzymes constituted by several subunits (like DNA polymerase 3) are call holoenzyme as well, because it will only perform correctly when all its subunits are present.
An analogy that can link with the process of respiration can be a factory. For example, the way that the factory processes raw goods to make manufactured goods is similar to how the respiratory system takes in molecules and breaks it down into energy.
Lysosome and the nucleolus, last time i checked these where it,
