Proteostasis is mediated by chaperone proteins and protease systems, together with cellular clearance mechanisms such as autophagy and lysosomal degradation.
Chaperone proteins control assembly and inaccurate folding by binding to and stabilizing partly or completely unfolded protein polypeptides till the polypeptide chain is completely synthesized. Chaperone proteins also confirm the stability of unfolded polypeptide chains as they are being translocated into the subcellular organelles.
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Effacement: The cervix – which is normally long and thick, measuring about 1-2 inches, starts to get shorter and thinner. This process is known as effacement. As the cervix gets more and more effaced, it gets shorter and shorter and “pulled up” into the lower part of the uterus.
Dilation: At the same time, the cervix softens and begins to open up – known as dilation. This widening, allows a smooth passage for the baby’s head and the rest of the body from the uterus into the vaginal canal.
It is endangered? Because a kirtland warbler is a big species.
