The vertebral column of an adult human being is composed of 33 vertebrae, of which 24 are known as articulating or movable vertebrae, and are separated from each other by an intervertebral disc. The remaining 9 vertebrae lack the intervertebral disc and form two sets of fused structures.
A change in the DNA sequence of a gene leads to a change in the nucleotide sequence in the messenger RNA, which can lead to a change in the amino acid sequence of the resulting protein.