Osteoporosis causes bone density to decrease due to decreased osteoblast activity, increased osteoclast activity, and external factors like long-term medication. Option B. All choices are potential causes.
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What are the factors that promote osteoporosis?</h3>
Let us first review what the bone cells are and their functions,
• Osteoprogenitores → in charge of osteocytes production
• Osteocytes → maintain the matrix
• Osteoblasts → Synthesize and secrete osteoid matrix that will later calcify
• Osteoclasts → Phagocytic cells in charge of osseous resorption and bone modulation.
Osteoporosis is a no-symptoms disease -silent- that causes a decrease in the bone mineral and mass density and might change the bone structure.
Osteoporosis weakens the bone until it breaks. So this affection becomes evident when a fracture occurs.
Several factors lead to osteoporosis development. Among them, we can mention,
- habits factors (lifestyle),
The increased rate of bone resorption is the major mechanism by which osteoporosis occurs. It deteriorates bone structure and decreases bone density.
Bone resorption and deterioration might be caused by
- a decrease in osteoblast activity, leading to the decrease in osteoid matrix formation and calcification,
- an increase in osteoclast activity, enhancing the activity of these phagocytic cells.
Other external factors also increase the probability of developing osteoporosis. Some of them are,
- long-term medications (for instance, those used in cancer treatment)
- excessive alcohol consumption and smoking
According to this framework, the potential causes of the Osteoporosis are Decreased osteoblast activity, Increased osteoclast activity, Secondary to external factors like drugs/cancers.
Hence, <u>option B is correct</u>, All choices are potential causes.
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