The ovary is the part of the female reproductive system that produces ova.
The ovary is an organ located in the female reproductive system that produces female reproductive cells or ova. The ovary is often paired and are firm, smooth and about the size of an almond. The ovaries are held by a membrane next to the uterus on both side of the lower abdomen. When an ovum is produced, it moves into the uterus through the fallopian tube, where it may be fertilized by a sperm. The ovary also secretes various hormones such as estrogen and progesterone that perform major roles in the menstrual cycle and fertility.
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Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
It enters the citric acid cycle and associates with a 4-carbon molecule, forming citric acid, and then through redox reactions regenerates the 4-carbon molecule.
Explanation:
Acetyl-CoA(2C) associates with oxalacetate(4C) to form citric acid(6C). Then through redox reactions, CO2 molecules result from decarboxylation (COOH becomes R-(R1)CH-R2). And through dehydrogenation H2 molecules are incorporated in NADH+ in FADH2, resulting in the 4-carbon molecule at the beginning (oxalacetate). That's why it's called a cycle(Kreb's cycle or citric acid cycle)
