Answer:
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ T regulatory cells) and B cells are involved in this disorder, thus new MS therapies seek damage prevention by resetting multiple components of the immune system. The currently approved therapies are immunoregulatory and reduce the number and rate of lesion formation but are only partially effective. This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation. The translational options target oligodendrocyte protection and myelin repair in animal models and assess their relevance in human. Remyelination may be enhanced by signals that promote myelin formation and repair. The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.Keywords: calpain, central nervous system, demyelination, fingolimod, glycolipids, lipids, multiple sclerosis, myelin, myelination, NKT cells, oligodendrocytes, remyelination, T cells
Explanation:
<span>Adrian’s
stroke most likely a</span>ffected the left hemisphere of the
frontal lobe of his brain- particularly the Broca’s area. Damage to this area leads
to Broca’s Aphasia and influences our ability to express and comprehend ideas,
and produce language (both written and spoken).
Answer:
other people, rebellion, lack of confidence, escape, misinformation
Do daily challenges such as doing as many pushups as you can one day and the next moving on to how many squats, in this day in age you can find many apps to work out at home with no equipment and for free.
Answer:
it would make the systems unbalanced, ruining the body. There are 10 systems
Circulatory
Respiratory
Nervous
Muscular
Skeletal
Digestive
Endocrine (hormones)
Lymphatic, or immune system
Reproductive
Integumentary (skin, hair)
if one becomes unbalanced or doesn't work the others cannot work, so i'm assuming a "self destruct"
hope this helps .-.
Explanation:
