Question

The figure below shows the incidence of Bruton's syndrome in the three generations of a family. Bruton syndrome is a rare genetic disorder that is characterized by the mutation in a o gene that prevents the development of certain immune cells. It is an X-linked recessive trait. Determine the genotypes of the individuals in the chart. Let $X^{B}$ represent the dominant Bruton allele and $X^{b}$ represent the recessive Bruton allele.

Answer 1

The genotype of the individuals is found below.

Genotypes

The disease is X-linked and recessive.  

Males are XY while females are XX. Males only need one recessive allele to become affected. Thus:

• affected males will be $X^bY$ while unaffected males will be $X^BY$
• affected females will be $X^bX^b$, unaffected females will be $X^BX^b$ or $X^BX^B$

Following these rules, the genotypes of individuals in the figure will be as follows:

1. $X^BY$          2.  $X^bX^b$       3.  $X^BY$       4.  $X^BX^b$ or $X^BX^B$

    5.   $X^bY$         6.  $X^bY$          7.   $X^bX^b$     8.  $X^BY$  

    9.   $X^BX^b$ or $X^BX^B$   10.   $X^bY$     11.   $X^bY$      12.   $X^bY$

     13.  $X^bX^b$

More on X-linked diseases can be found here: brainly.com/question/14889166

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