Answer:
Amino acid substitutions at the interaction interface may result in binding affinity changes, and thus affect the structure of the protein complex. ... This structural change may significantly affect the binding energy, and make the protein complex unstable
Explanation:
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Natural changed to the ecosystem relate to environmental shock that occur naturally. Natural changes include floods, volcanic activity, hurricanes, etc. They can be destructive, but they also have advantages. Floods have the contribution of nutrients to the soil which was lacking. It can also relocate fishes and organisms living in bodies of water which improves the ecosystem.
the same goes for the other
The brain analyzes thattt