Question

Which structure is the final step in the pain pathway and results in pain perception and interpretation?

Answer 1

Answer: Third-order neurons

Explanation:

Third-order neurons in the thalamus, brainstem, and midbrain project to the central nervous system, which allows pain perception and interpretation.

Also, the limbic and reticular tracts are activated by third-order neurons, resulting in arousal and emotional responses to pain.

When stimulated, nociceptors (first-order neurons) in the skin, muscles, joints, arteries, and viscera transmit pain impulses to the spinal cord.

Second-order neurons in the dorsal horn of the spinal cord transmit the pain impulse to higher brain areas via spinal pathways.

The thalamus is the primary relay station for pain impulses.