Question

Some bacterial cells are resistant to a variety of antimicrobials because they actively pump the drugs out of the cell.

Answer 1

True. Some bacterial cells are resistant to a variety of antimicrobials because they actively pump the drugs out of the cell.

A significant resistance mechanism in Gram-negative bacteria is drug efflux. It expel solutes from the cell. Antimicrobials and metabolites are just a few of the hazardous compounds that Efflux pumps help bacteria remove from their interior environments so they can regulate it.

The main efflux systems in Gram-negative bacteria are members of the RND superfamily and typically consist of an outer membrane protein channel, a periplasmic protein, and a cytoplasmic membrane pump. The most common example is  MFS (such as Bmr and Blt in Bacillus subtilis) and the ABC transporters.

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