True. Some bacterial cells are resistant to a variety of antimicrobials because they actively pump the drugs out of the cell.
A significant resistance mechanism in Gram-negative bacteria is drug efflux. It expel solutes from the cell. Antimicrobials and metabolites are just a few of the hazardous compounds that Efflux pumps help bacteria remove from their interior environments so they can regulate it.
The main efflux systems in Gram-negative bacteria are members of the RND superfamily and typically consist of an outer membrane protein channel, a periplasmic protein, and a cytoplasmic membrane pump. The most common example is MFS (such as Bmr and Blt in Bacillus subtilis) and the ABC transporters.
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