Question

If a person uses up his or her reserve supply of glycogen and still does not eat, sugar comes from the?

Answer 1

If a person uses up his or her reserve supply of glycogen and still does not eat, sugar comes from the muscle.

Although only liver glycogen directly contributes to the release of glucose into circulation, maintaining a healthy blood glucose concentration is one of the glycogen's key functions. Since skeletal muscles lack glucose 6-phosphatase, they are unable to release glucose, and muscle glycogen primarily serves as a local energy source for activity rather than a source of fuel to keep blood glucose levels stable while fasting.

In fact, the breakdown of muscle glycogen into lactate allows for its delivery to the liver, where it participates in the maintenance of euglycemia through the process of gluconeogenesis (Cori cycle).

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