Question

What appears to be a negative role of telomerase activity with regard to human health?.

Answer 1

Telomerase is active in most cancer cells.

What is the negative role of telomerase?

Telomerase is very active in cancer cells, replacing and lengthening any broken and shortened telomeres, which helps to explain why cancer is characterized by rapid and uncontrolled cell division. Telomere lengthening by telomerase allows cancer cells to multiply endlessly and develop swiftly.

Cancer cells would become inactive, cease dividing, and finally go through apoptosis if telomerase weren't present. Cancer cells may be rendered inactive and their ability to proliferate halted by substances that could inhibit telomerase or kill cells that manufacture the enzyme. However, telomerase-dependent cells including immune cells, sperm, and eggs may suffer if its activity is inhibited, which could have an adverse effect on fertility and the body's ability to fight off infection.

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