Answer: A and C - When the moon is in alignment with the Earth and Sun, then the tides will be strongest.
Answer:
a. destroyed
b. osteoclasts
c. proteolytic enzymes
d. hydrochloric acid
e. blood
f. low
Explanation:
Resorption is the loss of substance from any mineralized tissue, mediated by cellular and humoral systems of their own. The four mineralized tissues of our economy, bone, cement, dentin (mineralized fraction of the dentino-pulp functional complex) and enamel, offer different degrees of resistance to resorption. The bone has the greatest lability and the enamel the least. The fact that the bone tissue is the least resistant to resorption is used to move and reposition teeth by controlled forces (orthodontics); and the fact that the enamel is the most resistant has led to think that it does not suffer from resorption.
Osteoclasts They are the spring cells par excellence; they belong to the lineage of the monocitomacrophages. They are large, multinucleated mobile cells, with a clear area and a rough brush border that live for about two weeks and disappear by apoptosis (cell death programmed by fragmentation in membrane particles that allows their phagocytosis without inflammation). They are responsible for the destruction of the organic and inorganic parts of the mineralized bone fraction. They are active both in the processes of the physiological renewal of the bone and in those of its pathological loss.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The statement is true. DNA replication process happen during the cell cycle.