Question

Which 5-carbon intermediate of the citric acid cycle is converted to a 4-carbon molecule with the release of carbon dioxide?

Answer 1

The alpha- ketoglutarate is the  5-carbon intermediate of the citric acid cycle which converted to a 4-carbon molecule with the release of carbon dioxide

The first decarboxylation reaction in Krebs cycle ( known as  citric acid cycle ) is catalyzed by isocitrate dehydrogenase in which one six carbon atoms compound isocitrate is decarboxylated to yield five carbon atom containing alpha ketoglutaric acid.

The alpha- ketoglutarate is the  5-carbon intermediate of the citric acid cycle which is salt of alpha ketoglutaric acid. The last reaction in the citric acid cycle produces a product that is a substrate for the first reaction of the citric acid cycle.

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