The guidelines state that if the type of diabetes is not documented, the default is type 2.
The guidelines also instruct to use additional codes to identify long-term control with insulin (Z79. 4) or oral hypoglycemic drugs (Z79. 84).
The type of diabetes mellitus should always be clearly documented in the medical record for each date of service. However, if the type of diabetes mellitus is not documented in the medical record, the default ICD-10 diagnosis code is E11, type 2 diabetes mellitus.
Secondary diabetes can be defined as a diabetic condition that develops after the destruction of the beta-cells in the pancreatic islets and/or the induction of insulin resistance by an acquired disease (e.g. endocrinopathies) or others.
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Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
I saw this: Formaldehyde. ... Aluminum salts. ... Thimerosal. ... Chicken egg proteins. ... Gelatin. ... Antibiotics.
Explanation:
Just look up "What is in the flu vaccine" or "what ingredients can be found in a flu shot"
Hope this (kinda) helped :)
Osteoporosis affects the a) skeletal body system