Question

Tris(hydroxymethyl)aminomethane, known as TRIS or THAM, is a water-soluble base used in synthesizing surfactants and pharmaceuticals, as an emulsifying agent in cosmetics, and in cleaning mixtures for textiles and leather. In biomedical research, solutions of TRIS are used to maintain nearly constant pH for the study of enzymes and other cellular components. Given that the Pkb is 5.91, calculate the pH of 0.075 M TRIS.

Answer 1

Tris (as a pure compound normally supplied) is a base and its aqueous solutions are alcaline. It is not a buffer sensu stricto. To accumulate a buffering ability it sould be in equilibrium with the corresponding acid which is the protonated structure of Tris.

Is Tris damaging to humans?

The following acute (short-term) fitness consequences can also occur straight away or rapidly after publicity to Tris (2,3- Dibromopropyl) Phosphate: * Contact can irritate the pores and skin and eyes. * Tris (2,3-Dibromopropyl) Phosphate is a PROBABLE CARCINOGEN in humans.

Is Tris base toxic?

tris(hydroxymethyl)aminomethane

Potential Adverse human fitness effects and signs : Practically non-toxic. Non-toxic if swallowed (LD50 oral, rat > 5000 mg/kg). Non-toxic in contact with skin (LD50 skin> 5000 mg/kg). Not irritant to skin.

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