Question

Consider a lab-made protein that contains an er signal sequence at its n-terminus and a nuclear localization signal in its middle. what is the initial fate of the protein?

Answer 1

Ribosomes link a molecule to the er membrane as it is translated. However, the ribosome population is not static; is constantly moving through the ribosome.

Where can I get the signal sequence for proteins bound to the ER?

The endoplasmic reticulum (ER) is a network of tubules and sacs (cisternae) enclosed by membranes that spreads throughout the cytoplasm from the nuclear membrane.

In most eukaryotic cells, the endoplasmic reticulum is the largest organelle and is surrounded by a continuous membrane. Its membrane may account for half of all cell membranes, while the region occupied by the ER (the lumen, or cisternal space) may account for 10% of total cell volume.

learn more about  ER signal  refer

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