That it should be taken with water.
To prevent overdosing, SR forms should reach the gastrointestinal (GI) tract intact, thus give them to patients with water and advise them not to chew or crush them. They are ingested whole rather than being dissolved sublingually. It is preferable to take them one hour before meals, on an empty stomach.
Both angina and congestive heart failure are treated with oral nitrates. In the United States, more than 12 million prescriptions for the long-term use of oral nitrates were written in 1993. There are now three nitrate substances on the market in the United States: nitroglycerin, isosorbide dinitrate, and most recently, isosorbide mononitrate.
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