Ionotropic directly act and are for brief and rapid responses. Usually they're a part of the ion channel and then when the neurotransmitter binds to the receptor it then responds with opening the ion channels.
Metabotropic indirectly act and are for slower and long lasting responses. These responses can involve changes within the cell nucleus which influences the gene expression.
What is ionotropic receptor?
Ionotropic receptors are ligand-gated ion channels made from three, four, or five protein subunits that together form an ion-conducting pore within the center of the receptor. There are four families of ionotropic receptors, which differ in their molecular structure and therefore the ligands that open them.
How does a metabotropic receptor work?
When a ligand binds to those membrane-bound receptor proteins, the receptor activates intermediate proteins called G-proteins. These G-proteins can then activate enzymes, open ion channels, and initiate intracellular signaling cascades.
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