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Marina86 [1]
2 years ago
8

Tsu LV, Dienes JE, Dager WE. Vitamin K dosing to reverse warfarin based on INR, route of administration, and home warfarin dose

in the acute/critical care setting. Ann Pharmacother. 2012; 46:1617-26.
Medicine
1 answer:
lianna [129]2 years ago
7 0

Subsequent INR readings are influenced by the dose, method, and initial INR of vitamin K. For intravenous vitamin K doses of 2 mg or more, INR decrease is comparable. FFP preadministration has no effect on INR readings 48 hours or more after vitamin K administration.

What is Abstract of Vitamin K dosing to reverse warfarin based on INR, route of administration, and home warfarin dose in the acute/critical care setting?

  • Commonly, vitamin K is used to reverse the anticoagulant effects of warfarin. The ideal vitamin K dosage and delivery method that does not lengthen bridging therapy are still unclear.
  • To ascertain the elements affecting the level and pace of vitamin K-induced INR reversal in the acute/critical care setting.
  • 400 patients' charts from between February 2008 and November 2010 who got vitamin K to counteract the effects of warfarin were examined. International normalized ratios (INRs), intravenous or oral vitamin K doses, and whether or not fresh frozen plasma (FFP) was administered were among the information gathered. INRs were measured 12, 24, and 48 hours before vitamin K treatment.
  • At baseline, 12 hours, 24 hours, and 48 hours, respectively, intravenous vitamin K decreased INR more quickly than oral vitamin K (5.09, 1.91, 1.54, and 1.41 vs. 5.67, 2.90, 2.14, and 1.58). Subsequent INR values were impacted by baseline INR (p 0.001), method of administration (p 0.001), and vitamin K dosage (p 0.001). For intravenous vitamin K doses of 2 mg or more, there was a similar drop in INR. Home warfarin dose had no effect on INR responses to intravenous or oral vitamin K (p = 0.98 and 0.27, respectively). FFP had no effect on INR readings 48 hours later. Although larger vitamin K doses and longer anticoagulation bridge therapy appeared to be related, neither the incidence (p = 0.63) nor the duration (p = 0.61) were statistically significant.

To learn more about vitamin K doses visit:

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nikitadnepr [17]

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8 0
1 year ago
The [α] of pure quinine, an antimalarial drug, is −165. If a solution contains 69% quinine and 31% of its enantiomer (ee = 38%),
Elis [28]

Answer: The required [a] for slotion will be -62.7

Explanation:

The specific rotation of pure quinine= -165

% of pure quinine= 69%

% of its enantiomer=ee=31%

Enantiomer excess =(ee)=excess of a single enantiomer/entire mixture×100

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Excess of a single enantiomer=69% - 31%=38%

Entire mixture=69% + 31%= 100%

(ee)=38/100 × 100

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Net rotation= 0.69-0.31=0.38

Hence, [a] for solution will be = -0.38×165= -62.7

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So therefore, the nursing staff actions which would positively influence the client’s behavior is to help

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brainly.com/question/2347244

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