Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
D. An image you do not have the right to use
Explanation:
Since you don't have the rights to use the image it isn't considered a digital asset.
Answer:
1b. Accessibility 1c. Efficiency 1d. Relevance
2. $10 billion
3. False
4. All of them
5. Drone Delivery
Explanation:
1. Information technology is the study or use of systems (especially computers and telecommunications) for storing, retrieving, and sending information and it must be accurate, accessible, efficient and relevant.
2. Every year about $10 billion is spent on SCM (supply chain management software).
3. supply chain is the network of all the individuals, organizations, resources, activities and technology involved in the creation and sale of a product, from the delivery of source materials from the supplier to the manufacturer, through to its eventual delivery to the end user while software are just virtual tools use in the day to day activities.
4. Every activity mention is creating a new demand for the radio-frequency identification technology.
5. Drone delivery
Wear Your Seatbelt
Ignite Car
Observe other Drivers
Answer:
Following is given the detailed solution of each part. I hope it will help you!
Explanation: