Question

The ionic group coo- on succinate forms bonds with the succinate dehydrogenase

Answer 1

At neutral pH, the ionic group COO- on succinate makes bonds with the active site of succinate dehydrogenase. This bonding is required for succinate oxidation.

What is succinate oxidation?

In the Krebs cycle , succinate dehydrogenase catalyzes the oxidation of succinate to fumarate, with the resulting electrons being supplied to respiratory chain complex III to decrease oxygen and produce water.

SDH oxidizes succinate to fumarate during the citric acid cycle. SDH is structurally similar to fumarate reductase, an enzyme that catalyzes the opposite process during anaerobic respiration in bacteria.

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